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作者: Leila Tan|2024年3月16日

Medicines that are only available through the purchase of a prescription from a qualified medical professional are known as prescription pharmaceuticals. In spite of the fact that you can't pick them up off the shelf at a pharmacy as you can with over-the-counter medications, there are still those who choose to use them in order to assist in their weight loss efforts, and Naltrexone is one of the more popular options. Many people are aware that low dose Naltrexone has an influence on the management of blood glucose and recovery of the immune system, which in turn helps with weight loss. On the other hand, it is also recommended to certain patients that they use this medication more as an aid in losing weight, especially hypothyroid patients, who have a tendency to improve more quickly; however, is Naltrexone really should be your choice of weight loss method? Read the article to find out.


What Exactly Is Naltrexone?

Naltrexone is initially used as an opioid receptor antagonist to treat opioid addiction and alcohol dependence. It is FDA-approved for alcoholism and opiate addiction treatment. It competes for opiate receptors and displaces opioid medications from these receptors, thereby counteracting their effects. It has the ability to block all opiate receptors. These receptors are situated within the outer membrane of nerve cells in the nervous system.

When opioids attach to receptors, the interaction initiates a cascade of chemical changes within and between neurons, resulting in feelings of pleasure and pain alleviation. Naltrexone inhibits the sense of euphoria or pleasure in order to assist people stop taking these substances and remain abstinent. To lower alcohol intake, Naltrexone alters the connection between the hypothalamus, pituitary gland, and adrenal gland.

In recent years, low dose Naltrexone is also being used by doctors to help patients with illnesses ranging from chronic pain and a dysfunctional immune system to reducing inflammation, cancer, and mental health issues.



How Can Naltrexone Treatment Help With Weight Loss?

In modest doses, Naltrexone can assist individuals with obesity related risk factors to achieve their goals in chronic weight management. Low dose Naltrexone is an additional Naltrexone formulation that can aid in weight loss. There are multiple ways in which this contributes to weight loss. Evidence suggests that low dose Naltrexone can help you consume fewer calories by making food appear less appetising. You may discover that you no longer feel the need to snack frequently.

Additionally, low dose Naltrexone may stimulate the body's production of growth hormone. By promoting the formation of strong muscles and the breakdown of fat, growth hormone aids in the process of losing weight, and improving growth hormone levels is one of the good therapy for people who face obstacles on their weight loss journey.

Additionally, low dose Naltrexone modulates cellular resistance to insulin, which is a leading cause of obesity, diabetes, cardiovascular disease, and other chronic illnesses. Since low dose Naltrexone reduces insulin resistance, it also brings benefits beyond weight loss.

Hence, more companies are finding the right blueprint by combining low dose Naltrexone with various other medications, in order to tackle weight gain issue among obese objects, and it has been combined with the well-known antidepressant Bupropion, that has a name that we might be more familiar with, called Contrave.

Contrave is used in conjunction with a low-calorie diet and regular exercise to aid with weight loss and maintenance. This medication is prescribed to obese or morbidly obese patients with weight-related medical conditions. Contrave has been shown to help people lose considerable amounts of weight, but only when used correctly and in conjunction with a nutritious diet and regular exercise. While using this medication, research participants dropped between 5 and 15 percent of their body weight, according to data from clinical trials.


3 Main Factors Contribute To How Naltrexone Help With Weight Loss:

Controlling appetite

Low dose Naltrexone reduces food intake and normalises appetite by inhibiting the body's receptor, which inhibits the action of endorphin at the opioid receptor and prevents autoinhibition of proopiomelanocortin neurons. Utilising Naltrexone can assist balance your metabolism, bringing your hunger and resting energy expenditure more into sync.

Improve sleep

Naltrexone can also be used to treat certain patients who have trouble sleeping on a long-term basis. Low doses of Naltrexone medication are frequently associated with the effects of longer sleep duration. Contrary to popular belief, low-dose Naltrexone has been used to treat persistent fatigue outside of its approved indication.

As several cross-sectional studies have indicated that short sleep duration is associated with obesity and the risk of future weight gain in both adults and children, having a good sleeping cycle after taking low doses of Naltrexone can slow down or stop your weight gain. However, if you notice that you are constantly weary or sleepy when taking it, consult your doctor. This could indicate that you are in a depressive state. As sleep deprivation causes weight gain,

Lowering Insulin Resistance

Till date, there are no explicitly authorised drugs to treat insulin resistance. However, diabetic drugs such as metformin and thiazolidinediones, or TZDs, are insulin sensitizers that reduce blood glucose in part by lowering insulin resistance. Insulin resistance is one of the primary causes of obesity, and turns out the extraordinary anti-inflammatory effect of Naltrexone was able to reduce insulin resistance. Naltrexone decreases fasting insulin levels, and it has been shown to ameliorate insulin resistance caused by hyperinsulinemia. It does so by reprogramming macrophages to engage in anti-inflammatory activities, hence reducing insulin resistance.



What Is The Safe Dosage For Naltrexone Treatment?

In general, Naltrexone low dose therapy generally has a recommended dosage of 0.5 mg to 4.5 mg daily, in order to keep its label as "low dose". As Naltrexone is more effective when it's used with Bupropion together, recommended safe dosages containing 32 mg of Naltrexone and 360 mg of Bupropion are often recommended.

When used in conjunction with changes in lifestyle and a reduction in calories, studies have shown that this combination of drugs is more successful at causing weight loss than either drug used alone. Combining Naltrexone and Bupropion appears to be quite successful for clinically significant weight loss (over 5% of total body weight) over the course of 6 months and 1 year when paired with lifestyle management and moderate calorie restriction.

Your doctor may advise you to use Naltrexone for weight loss in increments. One half of a pill (25mg) is recommended at the outset, followed by another 25mg 1 hour later. After that, follow up with once weekly doses of 350 mg.


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Naltrexone For Weight Loss: What Are The Side Effects?

Regrettably, there is no perfect medication that can treat every possible ailment. Despite being a promising medicine in the fight against opioid addiction, alcohol addiction, weight loss, Naltrexone has a number of adverse effects:

Early stage

Mild adverse effects (Includes nausea and constipation) associated with the administration of low-dose Naltrexone typically diminish within a few weeks of treatment or medication withdrawal. According to recent drug research, one quarter of patients reported nausea and 19% of patients reported constipation when they first started taking Naltrexone.

As mentioned above, Naltrexone use may also result in weight loss on its own, however appetite reduction is often a desired side effect for those concerned about increased appetite or loss of more weight. This is often used for people seeking to quit smoking or starting drugs that are known to induce weight gain.

Middle stage

Certain patients who continued to take low dose Naltrexone for an extended period of time complained headaches, vertigo, and sleep disturbances. It has been proven that Naltrexone inhibits the synthesis of pro-inflammatory cytokines, which can cause migraines.

Maximum treatment period

As low dose Naltrexone can reduce tolerance to the abused substance, which can lead to overdose, it is only recommended for obese adults to take it for 1 year, even if you see significant improvement in your weight management progress.

In addition to the above-mentioned consequences, there may be psychological consequences. This range includes insomnia, paranoia, euphoria, abnormal mental processes, and hallucinations. This, combined with withdrawal symptoms and maybe post-acute withdrawal syndrome, is a lot to take in.



Sick Of Pills? Consider Alternatives Of Naltrexone For Weight Loss

In recent years, some research results concluded that Bupropion promotes weight loss in obese persons, whereas Naltrexone has no discernible impact. As a result, overweight and obese adults may investigate alternatives to Naltrexone to address weight gain difficulties.


Some people may turn to weight loss injections in order to achieve better weight loss results. Fat burning injections, also known as lipotropic injections, help you burn fat more quickly by speeding up your metabolism. This allows you to burn fat swiftly and efficiently while still looking amazing in a non-invasive manner. One of the more common options for weight loss injection is Saxenda and Ozempic.

Saxenda is an injectable prescription medicine that may help some overweight and obese patients who also have weight-related medical problems. It is also used together with diet and exercise, whereas Ozempic is an injectable drug used to treat type 2 diabetes in adults. It is taken once weekly. Although Ozempic is not classified as a weight reduction drug, several studies have shown that those who take it do lose weight.

However, weight loss injections have potential risks, some of which may be life-threatening. During drug testing, the medication in Saxenda caused rats and mice to develop thyroid gland cancers. Several of these tumours were malignant. Fortunately, Saxenda has not been shown to produce thyroid tumours or medullary thyroid cancer in humans. If medullary thyroid cancer is not diagnosed and treated promptly, it can be fatal. Thus, it is recommended to go for other lose weight options that may not involve consuming chemicals.


Exercise benefits every area of the body, aids in the maintenance of a healthy weight, boosting your immune system, and reduces the likelihood of contracting certain diseases . Regular exercise can prevent weight gain, type 2 diabetes, cardiovascular disease, and hypertension. In addition, these benefits include mental stability and better sleep. When you exercise, your body generates chemicals that improve your mood. In addition, developing the habit of exercise minimises your risk of despair and anxiety, which can be a good mental health treatment for patients suffering from chronic pain conditions and sleep disorders.

Not only does exercise assist obese women to lose weight and keep their body mass index in check, but it also promotes healthy ageing. By toning your physique and losing weight, you may preserve your skin's complexion and elasticity so that it does not sag as soon. Exercise like High-intensity interval training (HIIT) and combined with a healthy diet can help you maintain lean muscle mass, as HIIT workouts can burn a large number of calories in a short period of time, with some research claiming a 30-minute workout can burn over 500 calories.

Laser treatment

For people that are looking for speedier options, weight loss laser treatment has been known for its effects, pricing and less side effects. This is especially visible as the technology has advanced throughout the years. Most persons who get laser treatment should anticipate to drop right around 11kg. For most individuals, this is the equivalent of decreasing a complete trouser size, but it's different for everyone of us, and some people that have lower pain tolerance might be just looking for an option that is less painful than liposuction.

Thus, it will depend on how and where you want the fat to be eliminated from your body. For people who are seeking better experiences in their weight loss journey, CoolShaping Fat Freezing Treatment from Perfect Laser Clinics has just the right answer for you.


Why Choose CoolShaping Fat Freezing Treatment?

While the CoolShaping Fat Freezing Treatment at Perfect Laser Clinics is widely regarded as one of the most effective ways to get rid of stubborn fat fast, continued success requires a high-protein diet and consistent physical activity.

The CoolShaping Fat Freezing Treatment is a convenient technique to reduce stubborn fat since it prevents the accumulation of new fat cells after they have been eliminated. Unlike other cryolipolysis body sculpting treatments, it does not require a lengthy period to show its effects; often, patients see a difference in their body's shape within 1–2 months. The CoolSculpting Fat Freezing Treatment can eliminate as much as 27% of localised fat stores. As your skin regains its firmness after undergoing this body sculpting treatment, you will be able to keep your newfound elasticity.

Although this treatment does not guarantee quick results like liposuction does, it is non-invasive and carries the added benefit of not causing weight gain in the form of a rebound effect. This means that in addition to reducing your fat, you will also see an improvement in the elasticity of your skin.

Interested in having Perfect Laser Clinics assist you on your path to lose weight? Make an appointment for your risk-free trial of the CoolShaping Fat Freezing Treatment today in either Melbourne or Sydney, and see how it can help you achieve your ideal body weight!


Is Naltrexone suitable for pregnant women?

If you are pregnant or planning to become pregnant and are concerned about using Naltrexone, it is important to talk to your doctor about your alternatives. Benefits of Naltrexone use will be evaluated by your doctor to determine if the medicine is appropriate for you. When used appropriately, Naltrexone can save the life of an addicted pregnant woman. For this specific case, the dangers of drug abuse during pregnancy outweigh those of taking Naltrexone. The American FDA has currently assigned Naltrexone pregnancy risk category C. This class denotes that harm to the foetus has been observed in experimental animal investigations. However, more studies involving human individuals are needed to corroborate these results.

Can I take Naltrexone and continue to consume large quantities of food?

Since low dose Naltrexone blocks feedback inhibition, it could provide continuous release of melanocyte-stimulating hormone (MSH), which leads to a decrease in appetite and reduces your food cravings. So it's very unlikely you will feel like consuming lots of food, which may be in favour if you are on a weight loss program.

Why is weight loss treatment better than weight loss pills?

Many dietary supplements have no health risks, and some may actually help with goals like increasing feelings of fullness or decreasing appetite. Common ingredients in diet tablets have been linked to potentially harmful side effects like rapid heart rate, hypertension, anxiety, gastrointestinal distress, and lack of sleep. problems with the kidneys, the liver, or the rectal area (hematoma). Contrarily, there is no evidence that medically assisted weight loss causes any sort of internal harm, particularly to the organs.

Can I get a body profile analysis before CoolShaping Fat Freezing Treatment?

Prior to treatment, an experienced consultant at Perfect Laser Clinics will do a full body evaluation in order to establish the optimal treatment plan for you. Before undergoing treatment, you should inform our beauty consultants if you have any chronic skin conditions, such as eczema or metabolic conditions like diabetes.

How long does it take for the treatment to take effect?

The number of sessions required vary depending on the individual's condition and the size of the body area being treated. As compared to the method of using Naltrexone for weight loss, CoolShaping Fat Freezing Treatment has a more visible effect within the same time frame.


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